How Accurate Are the Recent Claims of the Dangers of the HPV-Vaccination Gardasil?

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Healthy Living – The Huffington Post
How Accurate Are the Recent Claims of the Dangers of the HPV-Vaccination Gardasil?
This question originally appeared on Quora.
Answer by Robyn Correll Carlyle, MPH

We should be highly skeptical of them.

But let me back up.

I'll get into why the science doesn't align with the reports you mentioned in a second. But first, I want you to keep something in mind. Politicians are not scientists. The Advisory Committee on Immunization Practices (ACIP), on the other hand, is the panel of experts that decides what vaccines will be recommended for the routine schedule, and they do so based on all available scientific evidence that shows the vaccine to be safe, effective, and necessary. If policy makers decide to require that all 7th graders have their meningitis vaccine, but not the HPV vaccine, it doesn't mean that the meningitis vaccine is more important or safer — it means that the policy makers decided it was. Scientists should determine what vaccines should be recommended, not politicians.

That being said, let's look at what the evidence says.

The HPV vaccine is at least as safe, if not safer, than the other recommended vaccines in use today in the U.S. Is it 100% safe? Of course not. No medical intervention is. And anybody demanding (or offering) absolute guarantees doesn't understand medicine. Because like it or not, all medical interventions have risks. There will always be someone who is allergic to something or doesn't respond properly or who has something going on that we don't know about. Medicine is not one-fits-all, and so there will be risks for some people. The big question is: do the benefits outweigh those risks?

And here is what we know about the risks associated with the HPV vaccine:

As of Spring 2013, more than 56 million doses of HPV vaccine have been administered in the United States. HPV4 (brand name: Gardasil) accounts for 99% of those doses [1], so I'll focus on that particular vaccine.

We have a number of ways to track vaccine safety after it comes out on the market. One of those is the Vaccine Adverse Event Reporting System (VAERS). Something important to note here: Anyone can report any reaction following a vaccine dose — even if they aren't sure that the vaccine caused the adverse event.

Number of serious and nonserious reports of adverse events after administration of quadrivalent human papillomavirus (HPV4) vaccine in females, by year — Vaccine Adverse Event Reporting System, United States, June 2006-March 2013*

* Total number of reports (serious and nonserious) = 21,194. In the Vaccine Adverse Event Reporting System, reports are classified as serious if the submitter reports one or more of the following: hospitalization, prolongation of an existing hospitalization, permanent disability, life-threatening illness, or death.
Human Papillomavirus Vaccination Coverage Among Adolescent Girls, 2007-2012, and Postlicensure Vaccine Safety Monitoring, 2006-2013 – United States

What this graph says is that between June 2006 and March 2013, there were a total of 21,194 adverse events reported to VAERS following a dose of HPV4. Does this mean that the HPV vaccine caused those 21,194 events? No. All it means is that those events happened after the vaccine was given.

This is where Jae Won Joh's point about correlation not equaling causation comes into play. If someone eats a peanut butter sandwich and then drives to work and gets into a car accident, does that mean that peanut butter sandwiches cause car crashes? Of course not. Just because something happens right after something else, it doesn't necessarily mean they had anything to do with each other.

So when you see that "1,968 adverse cases have been presented to the Japanese government, detailing severe medical side effects" [3], you have to take it at face-value. Lots of people suffer from a wide range of medical issues every day. What's important to find out is: were those medical issues actually caused by the vaccine, or are they just coincidental? You can't get that from reports alone.

These reporting systems are important, however, because they help scientists identify potential reactions that were too rare to spot during pre-licensing clinical trials. If we see enough reports of the same reaction, scientists do the research to see if those who received the vaccine have a greater risk of that happening than those who didn't.

And that's what we did.

The Vaccine Safety Datalink (VSD) analyzed specific adverse events — like Guillain-Barre syndome (GBS), stroke, seizures, and severe allergic reactions — following more than 600,000 doses of HPV4. They then compared the rates of those events to a population that didn't receive the HPV4 vaccine. They found that none of these severe reactions were any more common in those who got the vaccine than those who didn't. [4]

Other reports that the HPV vaccine has caused infertility (as the Japanese news articles have suggested), blood clots, autoimmune disorders, or death have all been examined, too. And there is no evidence that the HPV vaccine caused any of those serious reports. [5, 6, 7, 8]

What is probably caused by the vaccine are the same temporary side effects that we see with all vaccines in that age group:
fainting (adolescents faint a lot during any medical procedure)dizzinessnauseafever (1 in 10 people will get a mild fever, 1 in 60 a moderate one)headachepain and redness a the injection site
The worst that almost all people receiving the HPV vaccine can expect is feeling a little icky for a day or two.

The vaccine is so safe partly because of how it is made. The HPV vaccine is a recombinant vaccine, which means that it's made by taking virus-like proteins that are manufactured using yeast cells [9]. We don't use the whole virus, like we do in some other more widely accepted vaccines. In fact, it's the same technology that we use to make the Hepatitis B vaccine, which is recommended for babies on the day they are born. If the HPV vaccine were given at a younger age with the majority of the other vaccines, I wonder if we would even be having this debate right now.

Something else to note about that graph is that you'll see the number of reports have gone down despite vaccination coverage going up. Given that the vaccine hasn't changed, it's likely that the reports were caused more by fear and hype than the vaccine itself. 

So those are the risks, what are the benefits of the vaccine?

Almost all adults will get HPV at some point in their lifetime — often very shortly after their first sexual experience. But just because it's transmitted sexually doesn't mean that it only affects the sexually promiscuous. Penetration is not necessary. Anybody with fingers, a mouth, and genitals can get and spread HPV. Even virgins can get HPV. And when 80%+ of people get it, it's normal. It's part of every day life, like the staph on our skin or cold sores. Very few people can say "that I/my child won't get HPV" and mean it. Almost everybody gets HPV.

Thankfully, most people clear the infection with no problem. Some infections, however, can lead to a variety of cancers (see the table below). In fact HPV is estimated to cause 26,200 cancers every year in the United States [10], and 5% of all cancers worldwide [11].

Source for table and graph: CDC – How Many Cancers Are Linked with HPV Each Year?

Both HPV vaccines protect against the two-types of HPV that are most commonly associated with these cancers, and are credited for cutting the incidence of these HPV types in half. This is despite a really low coverage rate (less than half of all U.S. adolescents have received the full vaccination series) [12]. It's a highly effective vaccine. And while it's too early to have direct proof that it reduces cancer (that will take years), we know the vaccine reduces the HPV types that lead to most HPV-related cancers, as well as pre-cancerous lesions [13].

And in exchange for reducing our risk of a variety of cancers, the vast, vast majority of us face only having fever or pain and swelling at the injection site.

We have a vaccine against cancer. Let's have a large-scale conversation about that.

[1] CDC – HPV Vaccine Safety – Vaccine Safety
[2] Human Papillomavirus Vaccination Coverage Among Adolescent Girls, 2007-2012, and Postlicensure Vaccine Safety Monitoring, 2006-2013 – United States
[3]  Japan withdraws support for HPV vaccines due to infertility side effects – Live Free, Live Natural"
[4] Findings from the Vaccine Safety Datalink
[5] CDC – FAQ HPV Vaccine Safety – Vaccine Safety
[7] The Childhood Immunization Schedule and Safety: Stakeholder Concerns, Scientific Evidence, and Future Studies
[8] Autoimmune, neurological, and venous thromboembolic adverse events after immunisation of adolescent girls with quadrivalent human papillomavirus vaccine in Denmark and Sweden: cohort study | BMJ
[9] Gardasil HPV Vaccine (recombinant human papillomavirus quadrivalent vaccine)
[10] How Many Cancers Are Linked with HPV Each Year?
[11] National Cancer Institute
[12] Reduction in Human Papillomavirus (HPV) Prevalence Among Young Women Following HPV Vaccine Introduction in the United States, National Health and Nutrition Examination Surveys, 2003-2010
[13] Early effect of the HPV vaccination programme on cervical abnormalities in Victoria, Australia: an ecological study

More questions on Vaccination:How can I make the best informed decision on vaccination for a newborn baby in California?Is the flu shot dangerous for children/elderly people?How are vaccines tested before production?

Coconut Oil Benefits: 12 Facts About This Wonderful Ingredient
You’ve probably started noticing that coconuts and coconut oil suddenly seem to be all over the grocery shelves, from big bottles of the solid oil to products like coconut yogurt and coconut-infused granola. What’s with the sudden ubiquitousness of this tropical plant?

It could be because it’s starting to look like coconut oil may have come by its unhealthy reputation unfairly. Long avoided because it’s considered a source of harmful saturated fats, research is starting to show that coconut oil may actually be a source of healthy fats, along with being a versatile ingredient that has dozens of uses beyond cooking.

We’ve rounded up a dozen things we think you ought to know about coconut oil — some of them might surprise you!

Hydrogenated coconut oil is not a great choice: Coconut oil got its bad reputation in part because of its use when hydrogenated. Hydrogenated oils and trans fats are especially unhealthy because they both raise our LDL or “lethal” cholesterol while lowering our HDL or “healthy” cholesterol. If you purchase coconut oil, look for labels that say “virgin” and make sure it’s not hydrogenated or partially hydrogenated and contains no trans fats.

Vegans dig it: Because coconut oil is solid at room temperature, it makes a great substitute for butter, margarine, or other spreads. Vegans don’t eat any animal products, including butter or margarine, which makes coconut oil a great alternative for them.

So do Paleo dieters: People following a Paleo diet eschew dairy, which means they don’t eat butter. Many of them have turned to coconut oil as a delicious substitute.

They do have saturated fats: It’s true that coconut oil contains saturated fats — 12 grams per teaspoon, in fact. If you are supposed to be watching your saturated fat intake, talk to your doctor before adding coconut oil to your diet.

It’s rich in medium-chain fatty acids: Medium-chain fatty acids have molecules that are composed of eight to 10 carbon atoms, compared to the 12 or more found in the more-common long-chain fatty acids. There is some research indicating that MCTs can help with weight loss, though this potential effect isn’t fully established yet.

It’s delicious: Coconut oil doesn’t taste as strongly of coconut as coconut milk or meat, but it does have a lighter version of that flavour, without overpowering dishes. Try it spread on toast instead of butter! You might be quickly converted.

It’s not a miracle food: No single food is a magic bullet, coconut oil included. An internet search will bring up dozens of webpages claiming that coconut oil can do everything from clear up your acne to cure cancer. It’d be great if that were true, and research into the food continues, but there is no scientific evidence supporting the majority of the health claims made for coconut oil.

It’s a source of lauric acid: The majority of the saturated fat in coconut oil is in the form of lauric acid, which is why many consider it to be a healthier choice than other fat sources. There are studies that show that lauric acid can increase your HDL or “healthy” cholesterol and lower your LDL or “lethal” cholesterol.

It’s high in calories: Regardless of the form it comes in, each gram of fat has nine calories. So if you’re on a calorie-restricted diet, you’ll want to watch your coconut oil intake—like any oil, it’s high in calories. That doesn’t mean you can’t enjoy it in moderation, whether it’s for the taste or any potential health benefits; it just means you’ll have to account for it in your daily intake totals.

It’s great for your skin: Dreading dry winter skin? Buy a jar of coconut oil — it makes a great moisturizer from head to toe, particularly for dry lips and rough hands and feet.

Diaper cream: It’s thought that coconut oil has antibacterial and antifungal properties—that and the fact that it’s moisturizing and gentle makes it a great choice for an all-natural diaper cream or baby salve. As a bonus, it’s safe to use with cloth diapers.

Massage oil: Like other natural options, coconut oil is great to use for massages. And the fact that it’s solid at room temperature makes it a less messy option than liquid oils. You’ll be moisturized and relaxed!


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